Research staff and introductions

Principal Investigator:Ozaki Michitaka

Graduate school of Health Sciences, Hokkaido University
Faculty of Health Sciences, Health Innovation and Technology Center, Laboratory of Molecular and Function Bio-imaging

Faculty of Health Sciences, School of medicine
N12-W5, Kitaku, Sapporo 060-0812, Japan
TEL: 011-706-3337/4753  FAX: 011-706-3337/4753

Tokyo Medical University: Visiting associate professor
Keio University: Visiting professor
University of Tsukuba: Adjunct lecturer
Tsukuba Industrial Liaison and Cooperative Research Center: Visiting researcher
Bioproduction research institute, National Institute of Advanced Industrial Science and Technology and became: Visiting researcher

Academic records and professional experiences

March, 1984
    Faculty of medical school,
March, 1988
    Graduate school of medical school, Okayama University
April, 1984
    Second Division of Surgery, Okayama University
September, 1989
    Chief physician of surgery, Yamaguchi Nan-yo Hospital
September, 1991
    Third Division of Surgery, Tokyo Women’s Medical University
April, 1993
    Assistant professor, Tokyo Women’s Medical University
December, 1995
    Chairperson of Surgery, Minamiyamato Hospital
April, 1996
    Assistant director, Minamiyamato Hospital
August, 1997
    Research Fellow, Johns Hopkins University School of Medicine, Department of Surgery, Division of Transplantation
March, 1998
    Research Fellow, Johns Hopkins University School of Medicine, Department of Medicine, Division of Cardiology
October, 1999
    Research fellow, Transplantation Center, National Center for Child Health and Development
April, 2003
    Associate professor, Graduate school of Medicine, Okayama University
October, 2004
    Associate professor, Graduate school of medicine, Hokkaido University
June, 2007
    Specially-appointed professor, Graduate school of medicine, Hokkaido University
April, 2012
    Professor, Graduate school of health sciences, Hokkaido University

My career as surgeon has firstly started after graduation. In the early stage, I was interested in the field of organ transplantation in which important research problems have been recognized such as the suppression of rejection responses and the method of organ preservation. As my research subject at the graduate school, I embarked on the topic of organ preservation, especially oxidative stress caused by blood reperfusion. My doctoral degree was given to my work regarding the condition of free radical generation in vitro based on EPR method. Since then I have been working on the research topic of oxidative stress for long periods. It seems to me that first motivation is always important. Since my interest was particularly focused on the liver, in terms of oxidative stress on the liver and hepatocyte, organ preservation, ischemia/reperfusion injury for transplantation have been studied in molecular biological methods. At Johns Hopkins University I had conducted the research works on rac1 GTPase, as a regulator of oxidative stress, and the regulation (production and scavenging mechanism) of intracellular ROS (reactive oxygen species). At National Center for Child Health and Development I carried out the research about cell proliferation/death regulation by redox balances. Since I have moved to Hokkaido University, besides the continued topic on molecular mechanism of liver injury/reproduction and functional maintenance, I newly began the bioimaging research subjected for in vivo monitoring which enables to observe actual pathological conditions, which have been investigated.
I am currently conducting the research for visualization of intracellular molecular mechanisms using the imaging technique utilizing “light”, and in short, my laboratory can be called “Liver, Stress and Imaging Laboratory”. I would like to propel my research activity together with many collaborators rather than by myself, pleasantly and strictly.

Haga Sanae

The liver has tremendous regenerative potential, and it starts proliferating the number of cells and regains its original size upon injury or surgical removal. My major subject of research is to elucidate the mechanism for hepatic damage/regeneration. Proper functions of many molecules in hepatic cells are important to keep liver healthy in response to variable conditions. While I have been working on it, I recognized some difficulties in figuring out the cellular signaling in detail. Recently we are developing a strategy to analyze them using “optical probe” in chemiluminescent or fluorescent methods. I expect that this technique makes it possible to observe the molecular signaling in living organs on a real-time basis.

Umezawa Kazuo

Aichi Medical University

Uemoto Shinji

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery/ Department of Pediatric Surgery, Kyoto University


Morita Naoki

I had obtained the doctoral degree of science from the graduate school of science, Hokkaido University. I had been working as a research fellow of Japan Society for the Promotion of Science, Japan Science and Technology Agency, and Agency of Industrial Science and Technology. In 2001, I entered the National Institute of Advanced Industrial Science and Technology and became a group leader at bioproduction research institute. From the same year I concurrently experienced as a visiting associate professor at graduate school of agriculture, Hokkaido University, and at graduate school of medicine, Hokkaido University (until 2012). After that I have been working at graduate school of health sciences, Hokkaido University. Since 2008, I have started the collaborative work with this laboratory and learned the methods for experiments on cells as well as animals. Recently I’m working on the design/production of a probe for molecular-imaging and its usage. My hobbies; sporting, watching sports, driving a car, fishing and discovering good restaurants. My email address: Link to the website:

Bioproduction Research Institute

Kaneshima Yumi

I am currently working in this laboratory as a collaborative researcher. I have been engaging a project for years and I know well the good atmosphere in the lab. Despite the fact that I am the only one who was born in Sapporo among the people in the lab, I like neither snow, nor cold season, nor even hot weather. Now I enjoy working with the cheerful members here.