Original Articles

2016

      1. Sanae Haga, Yimin, and Michitaka Ozaki.  Relevance of FXR-p62/SQSTM1 pathway for survival and protectionof mouse hepatocytes and liver, especially with steatosis. BMC Gastroenterology (in press) IF: 2.101
      2. Shigeki Jin, Hideki Hyodoh, Kotaro Matoba, Fei Feng, Akira Hayakawa, Katsuhiro Okuda, Keiko Shimizu, Sanae Haga, Michitaka Ozaki, Koichi Terazawa. Development for the measurement of serum thiosulfate using LC–MS/MS in forensic diagnosis of H2S poisoning. Legal Medicine 22: 18–22, 2016. IF:1.442
      3. Richard Thomas Jennings, Erdenezaya Odkhuu, Akina Nakashima, Naoko Morita, Toshihiko Kobayashi, Ikuko Yamai, Miyako Tanaka, Takayoshi Suganami, Sanae Haga, Michitaka Ozaki, Yasuharu Watanabe, Yoshinori Nagai, Kiyoshi Takatsu, Takane Kikuchi-Ueda, Isao Ichimonji, Yoshihiro Ogawa, Kensuke Miyake, and Sachiko Akashi-Takamura. Inflammatory responses increase secretion of MD-1 protein. International Immunology  [Epub ahead of print]IF:2.536
      4. Kayo Mizobe, Koichi Yokosawa, Atsushi Shimojo, Michitaka Ozaki. Does Fasting Modulate Physio-Psychological Responses to Emotional Pictures? An Analysis by MEG, VAS and Biological Markers. Advanced Biomedical Engineering 5: 88–93, 2016. IF: –
      5. Naoki Morita, Sanae Haga, Yoshihiro Ohmiya, and Michitaka Ozaki. Long-term ex vivo and in vivo monitoring of tumor progression by using dual luciferases. Analytical Biochemistry 497; 24-26, 2016 IF: 2.219
      6. Nobuki Ichikawa, Kenichiro Yamashita, Tohru Funakoshi, Shin Ichihara, Moto Fukai, Masaomi Ogura, Nozomi Kobayashi, Masaaki Zaitsu, Tadashi Yoshida, Susumu Shibasaki, Yasuyuki Koshizuka, Yusuke Tsunetoshi, Masanori Sato, Takahiro Einama, Michitaka Ozaki, Kazuo Umezawa, Tomomi Suzuki, Satoru Todo.　Novel anti-inflammatory agent 3-[(dodecylthiocarbonyl)-methyl]-glutarimide ameliorates murine models of inflammatory bowel disease. Inflammation Research 65(3):245-60, 2016 IF:2.347

2015

      1. Michitaka Ozaki, Takeaki Ozawa, Yuma Yamada. “Development of a New In Vivo Optical Probe for Biological Diagnosis and Therapy”　(pp. 265-279) in “Innovative Medicine Basic Research and Development” Edited by K. Nakao, N. Minato, S. Uemoto, Springer OPEN, Tokyo, 2015
      2. Yuma Yamada, Kohei Nakamura, Jiro Abe, Mamaru Hyodo, Sanae Haga, Michitaka Ozaki, Hideyoshi Harashima. Mitochondrial delivery of Coenzyme Q10 via systemic administration using a MITO-Porter prevents ischemia/reperfusion injury in the mouse liver. Journal of Controlled Release 213:86-95. 2015 IF: 7.705
      3. Yuka Inaba, Tomoko Furutani, Kumi Kimura, Hitoshi Watanabe, Sanae Haga, Yoshiaki Kido, Michihiro Matsumoto, Yasuhiko Yamamoto, Kenichi Harada, Shuichi Kaneko, Seiichi Oyadomari, Michitaka Ozaki, Masato Kasuga, Hiroshi Inoue. Gadd34 regulates liver regeneration in hepatic steatosis. Hepatology 2015, 61(4): 1343–1356. IF:11.190

2014

      1. Sanae Haga, Takeaki Ozawa, Yuma Yamada, Naoki Morita, Izuru Nagashima, Hiroshi Inoue, Yuka Inaba, Natsumi Noda, Riichiro Abe, Kazuo Umezawa, Michitaka Ozaki. p62/SQSTM1 plays a protective role in oxidative injury of steatotic liver in a mouse hepatectomy model. Antioxid Redox Signal. 2014, 21(18): 2515-2530. IF:7.667
      2. Masanori Sato, Kazuaki Nakanishi, Sanae Haga, Masato Fujiyoshi, Motoi Baba, Kazuhiro Mino, Yimin, Haruki Niwa, Hideki Yokoo, Kazuo Umezawa, Yoshihiro Ohmiya, Toshiya Kamiyama, Satoru Todo, Akinobu Taketomi, Michitaka Ozaki. Anoikis induction and inhibition of peritoneal metastasis of pancreatic cancer cells by a nuclear factor-kappa B inhibitor, (-)-DHMEQ. Oncology Research 2014, 21(6):333–343. IF:0.916

2013

      1. Watanabe M, Yamashita K, Kamachi H, Kuraya D, Koshizuka Y, Shibasaki S,Asahi Y, Ono H, Emoto S, Ogura M, Yoshida T, Ozaki M, Umezawa K, MatsushitaM, Todo S. Efficacy of DHMEQ, a NF-κB Inhibitor, in Islet Transplantation: II.Induction DHMETreatmentAmeliorates Subsequent Alloimmune Responses andPermits Long-Term Islet Allograft Acceptance.Transplantation. 2013, Sep 15;96(5):454-62. IF:4.003
      2. Kuraya D, Watanabe M, Koshizuka Y, Ogura M, Yoshida T, Asahi Y, Kamachi H,Nakamura T, Harashima H, Ozaki M, Umezawa K, Matsushita M, Yamashita K, TodoS. Efficacy of DHMEQ, a NF-κB Inhibitor, in Islet Transplantation: I. HMGB1Suppression by DHMEQ Prevents Early Islet Graft Damage. Transplantation. 2013, Sep 15;96(5):445-453. IF:4.003
      3. Yimin, Masashi Kohanawa, Songji Zhao, Michitaka Ozaki, Sanae Haga, Guangxian Nan, Yuji Kuge, Nagara Tamaki. Contribution of Toll-Like Receptor 2 to the Innate Response against Staphylococcus aureus Infection in Mice. PLoS ONE 2013, 8(9): e74287.
      4. Mitsuru Hattori, Sanae Haga, Hideo Takakura, Michitaka Ozaki, and Takeaki Ozawa. Sustained accurate recording of intracellular acidification in living tissues with a photo-controllable bioluminescent protein. PNAS 2013, 110 (23) 9332-9337. IF: 9.681
      5. Hongjiang Qiao, Riichiro Abe, Nao Saito, Yasuyuki Fujita, Sanae Haga, Chun Wu, Yoshihiro Ohmiya, Michitaka Ozaki, Hiroshi Shimizu. Novel method for intravital monitoring of human cells using far-red luminescence probe in mice. Journal of Investigative Dermatology  2013, 133(3):841-843. IF: 6.314
      6. Saito N, Yoshioka N, Abe R, Qiao H, Fujita Y, Hoshina D, Suto A, Kase S, Kitaichi N, Ozaki M, Shimizu H. Stevens-Johnson syndrome/toxic epidermal necrolysis mouse model generated by using PBMCs and the skin of patients.　J Allergy Clin Immunol. 2013, 131(2):434-441. IF: 11.003
      7. Shibasaki S, Yamashita K, Goto R, Wakayama K, Tsunetoshi Y, Zaitsu M, Igarashi R, Haga S, Ozaki M, Umezawa K, Todo S.Immunosuppressive effects of DTCM-G, a novel inhibitor of the mTOR downstream signaling pathway.Transplantation. 2013, 95(4):542-550. IF:4.003
      8. Kohei Oashi, Hiroshi Furukawa, Hiroshi Nishihara, Michitaka Ozaki, Akihiko Oyama,Emi Funayama, Toshihiko Hayashi, Yuji Kuge and Yuhei Yamamoto. Pathophysiological Characteristics of Melanoma In-Transit Metastasis in a Lymphedema Mouse Model. Journal of Investigative Dermatology 2013 Feb;133(2):537-544. IF:6.314
      9. Chun Wu, Ke-Yong Wang, Xin Guo, Masanori Sato, Michitaka Ozaki, Shyohei Shimajiri, Yoshihiro Ohmiya, Yasuyuki Sasaguri. Rapid Methods of Detecting the Target Molecule in immunohistology using a Bioluminescence Probe. Luminescence: The Journal of Biological and Chemical Luminescence. 2013, 28(1):38-43. IF:1.731

2012

      1. Kenji Wakayama, Moto Fukai, Kenichiro Yamashita, Taichi Kimura, Gentaro Hirokata,Susumu Shibasaki, Daisuke Fukumori,Sanae Haga,Mitsuru Sugawara, Tomomi Suzuki, Masahiko Taniguchi, Tsuyoshi Shimamura,Hiroyuki Furukawa, Michitaka Ozaki, Toshiya Kamiyama,Satoru Todo. Successful Transplantation of Rat Hearts Subjected to Extended Cold Preservation with a Novel Preservation Solution. Transplant International 25:696-706, 2012. IF:2.921
      2. Shibasaki S, Yamashita K, Yanagawa Y, Goto R, Wakayama K, Hirokata G, Tsunetoshi Y, Zaitsu M, Igarashi R, Haga S, Ozaki M, Todo S.Dendritic cells conditioned with NK026680 prolong cardiac allograft survival in mice. Transplantation. 2012 Jun 27;93(12):1229-37. IF:4.003
      3. Toshiya Kamiyama, Masato Takahashi, Kazuaki Nakanishi, Hideki Yokoo, Hirofumi Kamachi, Nozomi Kobayashi, Michitaka Ozaki, Satoru Todo. α-fetoprotein, vascular endothelial growth factor receptor-1 and early recurrence of hepatoma. World J Gastroenterol. 2012 January 28; 18(4): 340-348　IF:2.471
      4. Michitaka Ozaki, Sanae Haga, Takeaki Ozawa. In vivo monitoring of liver damage by caspase-3 probe. Theranostics 2(2):207-14, 2012. IF: 7.806
      5. Shibasaki S, Yamashita K, Goto R, Oura T, Wakayama K, Hirokata G, Shibata T, Igarashi R, Haga S, Ozaki M, Todo S. NK026680 inhibits T-cell function in an IL-2-dependent manner and prolongs cardiac allograft survival in rats.Transpl Immunol. 2012 Jan;26(1):42-9. IF:1.459
      6. Ryoichi Goto, Kenichiro Yamashita, Takeshi Aoyagi, Shinya Ueki, Motohiro Uno, Tetsu Oura, Nozomi Kobayashi, Rumi Igarashi, Susumu Shibasaki, Kenji Wakayama, Gentaro Hirokata, Tomohiro Shibata, Kazuo Umezawa, Michitaka Ozaki, Satoru Todo.The Immunomodulatory Effect of Nuclear Factor-κB Inhibition by Dehydroxymethylepoxyquinomicin in Combination with Donor-specific Blood Transfusion. Transplantation.2012 Apr 27;93(8):777-786. IF:4.003
      7. Kenichi Shimizu, Satoshi Konno, Michitaka Ozaki, Kazuo Umezawa, Kenichiro Yamashita, Satoru Todo, Masaharu Nishimura. Dehydroxymethylepoxyquinomicin (DHMEQ), a novel NF-kappaB inhibitor, inhibits allergic inflammation and airway remodeling in murine models of asthma. Clinical Experimental Allergy.2012 42:1273-1281 IF:5.032
      8. Tohru Funakoshi, Kenichiro Yamashita, Nobuki Ichikaw, Moto Fukai, Tomomi Suzuki, Ryoichi Goto, Tetsu, Oura, Nozomi Kobayashi, Takehiko Katsurada, Shin Ichihara, Michitaka Ozaki, Kazuo Umezawa, Satoru Todo. A novel NF-κB inhibitor, dehydroxymethyl epoxyquinomicin, ameliorates inflammatory colonic injury in mice. Journal of Crohn’s and Colitis,6:215-225,2012. IF:2.566

2011

      1. Masatoshi Takeiri, Miyuki Tachibana, Ayumi Kaneda, Ayumi Ito, Yuichi Ishikawa, Shigeru Nishiyama, Ryoichi Goto, Kenichiro Yamashita, Susumu Shibasaki, Gentaro Hirokata, Michitaka Ozaki, Satoru Todo, and Kazuo Umezawa. Inhibition of macrophage activation and suppression of graft rejection by DTCM-glutarimide, a novel piperidine derived from the antibiotic 9-methylstreptimidone. Inflammation Research,60:879-888,2011 IF:2.109
      2. Takahiro Einama, Hirofumi Kamachi, Hiroshi Nishihara, Shigenori Homma, Hiromi Kanno, Kenta Takahashi, Ayami Sasaki, Munenori Tahara, Kuniaki Okada, Shunji Muraoka, Toshiya Kamiyama, Yoshihiro Matsuno, Michitaka Ozaki, Satoru Todo. Co-expression of Mesothelin and CA125 Correlates with Unfavorable Patient Outcome in Pancreatic Ductal Adenocarcinoma. Pancreas .40(8):1276-82,2011　IF:2.386

2010

      1. Mino K, Ozaki M, Nakanishi K, Haga S, Sato M, Kina M, Takahashi M, Takahashi N, Kataoka A, Yanagihara K, Ochiya T, Kamiyama T, Umezawa K, Todo S. Inhibition of nuclear factor-kappaB (NF-κB) suppresses peritoneal dissemination of gastric cancer by blocking cancer cell adhesion. Cancer Sci, 102(5):1052-1058, 2010. IF:3.325
      2. Shusaku Takahashi, Toshiya Kamiyama, Utano Tomaru, Akihiro Ishizu,Toshiyuki Shida, Mineji Osaka, Yutaka Sato, Yutaka Saji,Michitaka Ozaki and Satoru Todo　 Frequency and pattern of expression of the stem cell marker CD133 have strong prognostic effect on the surgical outcome of colorectal cancer patients. Oncology Reports 24(5):1201-12, 2010. IF:1.835
      3. Oka M, Sakaguchi M, Okada T, Nagai H, Ozaki M, Yoshioka T, Inoue H, Mukaida N, Kikkawa U, Nishigori C. Signal transducer and activator of transcription 3 upregulates interleukin-8 expression at the level of transcription in human melanoma cells. Experimental Dermatology 19(8):e50-5, 2010. IF:3.543
      4. Sasaki A, Kamiyama T, Yokoo H, Nakanishi K, Kubota K, Haga H, Matsushita M, Ozaki M, Matsuno Y, Todo S.　 Cytoplasmic expression of CD133 is an important risk factor for overall survival in hepatocellular carcinoma. Oncology Reports  24(2):537-46.　2010. IF: 1.835
      5. Tetsuya Ogino, Michitaka Ozaki and Akihiro Matsukawa.　Oxidative stress enhances granulocytic differentiation in HL 60 cells, an acute promyelocytic leukemia cell line. Free Radical Research 44(11) 1328-1337. 2010. IF: 2.878
      6. Sanae Haga, Naoki Morita, Kaikobad Irani, Masato Fujiyoshi, Tetsuya Ogino, Michitaka Ozaki. p66Shc plays a pivotal role in impaired liver regeneration in aged mice by a redox-dependent mechanism. Laboratory Investigation 90, 1718-1726, 2010. IF:3.641 ※ジャーナルの表紙を飾りました。
      7. Asuka Hamasaka, Naoya Yoshioka, Satoshi Kishino, Kazuo Umezawa, Michitaka Ozaki, Satoru Todo, Riichiro Abe, Hiroshi Shimizu.　Topical application with DHMEQ, a novel NF-kB inhibitor, improves atopic dermatitis in murine model. The Journal of Allergy and Clinical Immunology 126, 400-403, 2010.　 IF:11.003
      8. Tohru Takahashi, Shuichiro Matsumoto, Michiaki Matsushita, Hirofumi Kamachi, Yosuke Tsuruga, Hironori Kasai, Masaaki Watanabe, Michitaka Ozaki, Hiroyuki Furukawa, Kazuo Umezawa, Satoru Todo. Donor pretreatment with DHMEQ improves islet transplantation. Journal of Surgical Research 163, e23-34, 2010. IF:2.247
      9. Nobumoto Tomioka, Keiko Morita, Nozomi Kobayashi, Mitsuhiro Tada, Tomoo Itoh, Soichiro Saitoh, Masao Kondo, Norihiko Takahashi, Akihiko Kataoka, Kazuaki Nakanishi, Masato Takahashi, Toshiya Kamiyama, Michitaka Ozaki, Takashi Hirano and Satoru Todo　Array Comparative Genomic Hybridization (CGH) analysis revealed four genomic prognostic biomarkers for primary gastric cancers. Cancer Genetics and Cytogenetics. 201: 6-14: 2010. IF:1.389
      10. Daiju Iwata, Nobuyoshi Kitaichi, Akiko Miyazaki, Kazuya Iwabuchi, Kazuhiko Yoshida, Kenichi Namba, Michitaka Ozaki, Shigeaki Ohno, Kazuo Umezawa, Kenichiro Yamashita, Satoru Todo, Susumu Ishida, and Kazunori Onoe. Amelioration of Experimental Autoimmune Uveoretinitis with Nuclear Factor-κB Inhibitor Dehydroxy Methyl Epoxyquinomicin in Mice. Investigative Ophthalmology & Visual Science　51:2077-2084, 2010.  IF: 3.597

2009

      1. Chun Wu, Kazuhiro Mino, Hidetoshi Akimoto, Makiko Kawabata, Koji Nakamura, Michitaka Ozaki, Yoshihiro Ohmiya. In vivo far-red luminescence imaging of a biomarker based on BRET from Cypridina bioluminescence to an organic dye. PNAS 106(37): 15599-15603 , 2009. IF: 9.681
      2. Y. Umeda, H. Iwagaki, M. Ozaki, T. Ogino, T. Iwamoto, R. Yoshida, S. Shinoura, H. Matsuda, H. Sadamori, N. Tanaka, and T. Yagi. Refractory response to growth factors impairs liver regeneration after hepatectomy in patients with viral hepatitis. Hepato-gastroenterology 56(93): 971-977 , 2009. IF:0.658
      3. Sanae Haga, S. James Remington, Naoki Morita, Keita Terui, and Michitaka Ozaki. Hepatic Ischemia Induced Immediate Oxidative Stress after Reperfusion and Determined the Severity of the Reperfusion-induced Damage. Antioxidants & Redox Signaling 11; 2563-2572, 2009. IF: 8.456
      4. Osamu Ikeda, Michitaka Ozaki, Soichiro Murata, Ryota Matsuo, Yoritaka Nakano, Motonobu Watanabe, Katsuji Hisakura, Andriy Myronovych; Nobuhiro Ohkohchi. Autonomic regulation of liver regeneration after partial hepatectomy in mice. Journal of Surgical Research 152(2): 218-223,2009. IF: 2.247
      5. Ogino T, Ozaki M, Hosako M, Omori M, Okada S, Matsukawa A. Activation of c-Jun N-terminal kinase is essential for oxidative stress-induced Jurkat cell apoptosis by monochloramine. Leukemia Research 33(1):151-158, 2009. IF: 2.923
      6. Hidetoshi Akimoto, Hyuck Joon Kwon, Michitaka Ozaki, Kazunori Yasuda, Ken-ichi Honma, Yoshihiro Ohmiya. In vivo bioluminescence imaging of bone marrow-derived cells in brain inflammation. Biochemical and Biophysical Research Communications 380:844-849, 2009. IF: 2.484
      7. Sanae Haga, Michitaka Ozaki*, Hiroshi Inoue, Yasuo Okamoto, Wataru Ogawa, Kiyoshi Takeda, Shizuo Akira, Satoru Todo. The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation. Hepatology 49:204-214, 2009. IF: 11.665

2008

      1. Yi M, Kohanawa M, Ozaki M, Haga S, Fujikawa K, Zhao S, Kuge Y, Tamaki N. Mutual modulation between interleukin-10 and interleukin-6 induced by Rhodococcus aurantiacus infection in mice. Microbes and Infection 10(14-15):1450-8, 2008. IF: 3.101
      2. N. Gotohda, H. Iwagaki, M. Ozaki, T. Kinoshita, M. Konishi, T. Nakagohri, S. Takahashi, S. Saito, T. Yagi, N. Tanaka. Deficient response of IL-6 impaired liver regeneration after hepatectomy in patients with viral hepatitis. Hepato-Gastroenterology 55(85):1439-44, 2008.
      3. Naoto Gotohda, Hiromi Iwagaki, Michitaka Ozaki, Taira Kinoshita, Masaru Konishi, Toshio Nakagohri, Shinichiro Takahashi, Shinya Saito, Takahito Yagi, Noriaki Tanaka. The significant correlation between surgical stress of hepatectomy and changes in the serum levels of HGF, IL-6 and soluble Fas in the patients with viral hepatitis. Hepato-Gastroenterology 55(85):1400-3, 2008.
      4. Tomomi Suzuki, Kenichiro Yamashita, Wataru Jomen, Shinya Ueki, Takeshi Aoyagi, Moto Fukai, Hiroyuki Furukawa, Kazuo Umezawa, Michitaka Ozaki, Satoru Todo. The novel NF-kB inhibitor, Dehydroxymethylepoxyquinomicin (DHMEQ) prevents local and remote organ injury following intestinal ischemia/reperfusion in rats. Journal of Surgical Research 149(1):69-75, 2008. IF: 2.247
      5. Watanabe E, Mochizuki N, Ajima H, Ohno K, Shiino M, Umezawa K, Fukai M, Ozaki M, Furukawa H, Todo S, Kishino S. A simple and reliable method for determining plasma concentration of dehydroxymethylepoxyquinomicin by high performance liquid chromatography with mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 871: 32-36, 2008. IF: 2.888
      6. Yoshiaki Miura, Magumi Hato, Yasuro Shinohara, Hiromitsu Kuramoto, Jun-ichi Furukawa, Masaki Kurogochi, Hideyuki Shimaoka, Mitsuhiro Tada, Kazuaki Nakanishi, Michitaka Ozaki, Satoru Todo, and Shin-Ichiro Nishimura. BlotGlycoABCTM: An integrated glycoblotting technique for rapid and large-scale clinical glycomics. Mol Cell Proteomics 7(2):370-377, 2008. IF：7.398
      7. Ryota Matsuo, Nobuhiro Ohkohchi, Soichiro Murata, Osamu Ikeda, Yoritaka Nakano, Motonobu Watanabe, Katsuji Hisakura, Andriy Myronovych, Tomomi Kubota, Hisashi Narimatsu, Michitaka Ozaki. Platelets strongly induce hepatocyte proliferation with IGF-1 and HGF in vitro. Journal of Surgical Research 145(2):279-286, 2008. IF: 2.247
      8. Hui-qi Zhang, Sanae Haga, Moto Fukai, Yuko Oikawa, Hiroshi Inoue, Wataru Ogawa, Arihiko Kano, Atsushi Maruyama, Xin-Yuan Fu, Hiroyuki Furukawa, Satoru Todo, Shin Enosawa, Michitaka Ozaki*. Identification of de novo STAT3 target gene in liver regeneration. Hepatology Research 38(4):374-384, 2008. IF: 2.199
      9. Sanae Haga, Keita Terui, Moto Fukai, Yuko Oikawa, Kaikobad Irani, Hiroyuki Furukawa, Satoru Todo, Michitaka Ozaki*. Preventing hypoxia/reoxygenation damage to hepatocytes by p66SHC ablation: up-regulation of anti-oxidant and anti-apoptotic proteins. Journal of Hepatology 48; 422-432, 2008. IF: 9.264

2007

      1. Takanori Oyama, Hiroshi Sadamori, Hiroyoshi Matsukawa, Hiroshi Murata, Yuzou Umeda, Yasuhiro Watanabe, Michitaka Ozaki, Hiromi Iwagaki, Noriaki Tanaka, Takahito Yagi. Small liver graft regenerates through immediate increase of HGF and IL-6 – possible involvement of sinusoidal shear stress in small liver graft. Hepato-gastroenterology 54:2078-2083, 2007.
      2. Hiroki Suemoto, Katsuhiro Nishioka, Misako Sato, Akira Ooshima, Shunji Itoh, Ikuji Hatamura, Michitaka Ozaki, Attila Braun, Erika Gustafsson, Reinhard Fassler. Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling. Developmental Biology 15;312:572-581, 2007. IF: 4.069
      3. Hiroshi Murata, Takahito Yagi, Hiromi Iwagaki, Tetsuya Ogino, Hiroshi Sadamori, Hiroyoshi Matsukawa, Yuzoh Umeda, Sanae Haga, Noriaki Takaka, Michitaka Ozaki*. The mechanism of impaired regeneration of fatty liver in mouse partial hepatectomy model. Journal of Gastroenterology and Hepatology  22:2173-2180, 2007. IF: 2.865

2006

      1. Hideaki Miyaso, Yoshinori Morimoto, Michitaka Ozaki, Susumu Shinoura, Yasuhiro Choda, Hiroshi Murata, Goutaro Katsuno, Kamul Huda, Hideo Takahashi, Noriaki Tanaka and Hiromi Iwagaki. Protective Effects of Nafamostat Mesilate on Liver Injury Induced by Lipopolysaccharide in Rats: Possible Involvement of CD14 and TLR-4 Down-regulation on Kupffer Cells. Digestive Diseases and Sciences 51(11);2007-2012, 2006. IF: 2.117
      2. Shinya Ueki, Kenichiro Yamashita, Takeshi Aoyagi, Sanae Haga, Tomomi Suzuki, Tomoo Itoh, Masahiko Taniguchi, Tsuyoshi Shimamura, Hiroyuki Furukawa, Michitaka Ozaki, Kazuo Umezawa, Satoru Todo. Control of allograft rejection by applying a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin. Transplantation 82(12):1720-1727, 2006. IF:4.003
      3. Toshiya Kamiyama, Masato Takahashi, Takahito Nakagawa, Kazuaki Nakanishi, Hirofumi Kamachi, Tomomi Suzuki, Tsuyoshi Shimamura, Masahiko Taniguchi, Michitaka Ozaki, Michiaki Matsushita, Hiroyuki Furukawa, Satoru Todo. AFPmRNA detected in bone marrow by real-time quantitative RT-PCR analysis predicts survival and recurrence after curative hepatectomy for hepatocellular carcinoma. Annals of Surgery 244; 451-463, 2006. IF: 7.492
      4. Kamrul ASM Huda, Lei Guo, Sanae Haga, Hiroshi Murata, Tetsuya Ogino, Moto Fukai, Takahito Yagi, Hiromi Iwagaki, Noriaki Tanaka, Michitaka Ozaki. The ex vivo adenoviral gene transfer of constitutively activated STAT3 reduced post-transplant liver injury and promoted regeneration in a 20% rat partial liver transplant model. Transplant International 19:415-423, 2006. IF: 2.921
      5. Kazuhisa Hiramatsu, Tetsuya Ogino, Michitaka Ozaki, Shigeru Okada. Monochloramine inhibits ultraviolet B-induced p53 activation and DNA repair response in human fibroblasts. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research 1763:188-196, 2006. IF: 5.538

2005

      1. Tetsuya Ogino, Mutsumi Hosako, Kazuhisa Hiramatsu, Masako Omori, Michitaka Ozaki, Shigeru Okada. Oxidative modification of Iκ-B by monochloramine inhibits tumor necrosis factor-alpha-induced NF-κB activation. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research 1746:135-42, 2005. IF: 5.538
      2. Tsukiyama S, Matsushita M, Kamachi H, Matsumoto S, Morita T, Kobayashi S, Tamura H, Ozaki M, Todo S. Transduction of exogenous Stat3 into dispersed islet induces proliferation of rat pancreatic-cell. Tissue Engineering Part A 12: 131-140, 2006. IF: 4.022
      3. Naoto Gotohda, Hiromi Iwagaki, Michitaka Ozaki, Masaru Konishi, Toshio Nakagohri, Shinichiro Takahashi, Takahiro Yagi, Taira Kinoshita and Noriaki Tanaka. The role of a Protease Inhibitor against Hepatectomy. Hepato-Gastroenterology 53: 115-119, 2006. IF: 0.658
      4. Hideaki Miyaso, Yoshinori Morimoto, Michitaka Ozaki, Sanae Haga, Susumu Shinoura, Yasuhiro Choda, Hiromi Iwagaki and Noriaki Tanaka. Obstructive jaundice increases sensitivity to lipopolysaccharide via TLR4 upregulation: Possible involvement in gut-derived hepatocyte growth factor-protection of hepatocytes. Journal of Gastroenterology and Hepatology 20 (12): 1859-1866, 2005. IF: 2.865
      5. Sanae Haga, Wataru Ogawa, Hiroshi Inoue, Keita Terui, Tetsuya Ogino, Rumi Igarashi, Kiyoshi Takeda, Shizuo Akira, Hiroyuki Furukawa, Satoru Todo, Shin Enosawa, Michitaka Ozaki*. Compensatory recovery of liver mass by Akt-mediated cellular hypertrophy in liver-specific STAT3-deficient mice. Journal of Hepatology 43(5): 799-807, 2005. IF:9.264
      6. Kosei Maemura, Qizhi Zheng, Tatehiko Wada, Michitaka Ozaki, Sonshin Takao, Takashi Aikou, Gregory B Bulkley, Andrew S Klein, Zhaoli Sun. Reactive oxygen species are essential mediators in antigen presentation by Kupffer cells. Immunology and Cell Biology 83 (4): 336 – 343, 2005. IF: 3.661
      7. Xiao Ping Yang, Kaikobad Irani, Subhendra Mattagajasingh, Anthony DiPaula, Firdous Khanday, Michitaka Ozaki, Karen Fox-Talbot, William M. Baldwin, III, and Lewis C. Becker. Signal Transducer and Activator of Transcription 3{alpha} and Specificity Protein 1 Interact to Upregulate Intercellular Adhesion Molecule-1 in Ischemic-Reperfused Myocardium and Vascular Endothelium. Arteriosclerosis Thrombosis and Vascular Biology 25:1395-1400, 2005. IF: 6.368
      8. Yoshimi Fujimoto, Hiromi Iwagaki, Michitaka Ozaki, Hiroshi Murata, Sun Dong Sheng, Hiroshi Sadamori, Hideo Kohka Takahashi, Masahiro Nishibori, Noriaki Tanaka, Takahito Yagi: Involvement of Prostaglandin receptors (EPR2-4) in in vivo immunosuppression of PGE-2 in rat skin transplant model. International Immunopharmacology 11:1131-1139, 2005. IF: 2.376
      9. Dong Sheng Sun, Hiromi Iwagaki, Michitaka Ozaki, Tetsuya Ogino, Satoshi Kusaka, Yoshimi Fujimoto, Hiroshi Murata, Hiroshi Sadamori, Hiroyoshi Matsukawa, Noriaki Tanaka, Takahito Yagi. Prolonged survival of donor-specific rat intestinal allograft by administration of bone-marrow-derived immature dendritic cells. Transplant Immunology 14: 17-20, 2005. IF: 1.459
      10. Kenji Matsushita, Munekazu Yamakuchi, Craig N Morrell, Michitaka Ozaki, Brian O’Rourke, Kaikobad Irani, and Charles J Lowenstein：Vascular endothelial growth factor regulation of Weibel-Palade body exocytosis. Blood 105: 207 – 214, 2005. IF: 9.898
      11. Frank Hoentjen, R. Balfour Sartor, Michitaka Ozaki, and Christian Jobin：STAT3 regulates NF-κB recruitment to the IL-12p40 promoter in dendritic cells. Blood 105: 689-696, 2005. IF: 9.898

2004

      1. Byeong Hwa Jeon, Gaurav Gupta, Young Chul Park, Bing Qi, Azeb Haile, Firdous A. Khanday, Yan-Xia Liu, Jin-Man Kim, Michitaka Ozaki,Anthony R. White, Dan E. Berkowitz, Kaikobad Irani.：Apurinic/Apyrmidinic Endonuclease 1 Regulates Endothelial NO Production and Vascular Tone. Circulation Research 95: 902-910, 2004. IF: 9.489
      2. Keita Terui, Shin Enosawa, Sanae Haga, Hui Qi Zhang, Naomi Onuma, Michitaka Ozaki*： Stat3 confers resistance against hypoxia/reoxygenation-induced oxidative injury in hepatocytes through upregulation of Mn-SOD. Journal of Hepatology 41: 957-965, 2004. IF: 9.264
      3. Naoshi Mitsuoka, Hiromi Iwagaki, Michitaka Ozaki, Sun Dong Sheng, Hiroshi Sadamori, Hiroyoshi Matsukawa, Yoshinori Morimoto, Junji Matsuoka, and Noriaki Tanaka, Takahito Yagi: The impact of portal infusion with donor-derived bone marrow cells and intracellular cytokine expression of graft-infiltrating lymphocytes on the graft survival in rat small bowel transplant model. Transplant Immunology 13: 155-160, 2004. IF: 1.459
      4. Lei Guo, Sanae Haga, Shin Enosawa, Katsutoshi Naruse, Yasushi Harihara, Yasuhiko Sugawara, Masatoshi Makuuchi, Michitaka Ozaki*: Improved hepatic regeneration with reduced injury by redox factor-1 in a rat small-sized liver transplant model. American Journal of Transplantation 4: 879- 887, 2004. IF: 6.394
      5. Keita Terui, Shin Enosawa, Sanae Haga, Naomi Ohnuma, Michitaka Ozaki*: Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp70 induction. Biochemical Journal 380: 203-209, 2004. IF: 4.897
      6. Hiroshi Inoue, Wataru Ogawa, Michitaka Ozaki, Sanae Haga, Michihiro Matsumoto, Hiroyuki Mori, Kensuke Furukawa, Naoko Hashimoto, Yoshiaki Kido, Toshiyuki Mori, Hiroshi Sakaue, Kiyoshi Teshigawara, Shiyu Jin, Haruhisa Iguchi, Ryuji Hiramatsu, Delek Leroith, Kiyoshi Takeda, Shizuo Akira & Masato Kasuga: Role of Stat-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nature Medicine 10(2): 168 -174, 2004. IF: 22.462

2003

      1. Sanae Haga, Keita Terui, Hui Qi Zhang, Shin Enosawa, Wataru Ogawa, Hiroshi Inoue, Torayuki Okuyama, Kiyoshi Takeda, Shizuo Akira, Tetsuya Ogino, Kaikobad Irani, Michitaka Ozaki*: Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms. Journal of Clinical Investigation 112:989-998, 2003. IF:13.069
      2. Sakamoto N, Sun Z, Brengman ML, Maemura K, Ozaki M, Bulkley GB, Klein AS: Hepatic reticuloendothelial system dysfunction after ischemia-reperfusion: Role of Rho-selectin-mediated neutrophil accumulation. Liver Transplantation 9(9): 940-948. 2003. IF: 3.386
      3. Michitaka Ozaki*, Sanae Haga, Hui Qi Zhang, Kaikobad Irani, and Seiichi Suzuki. : Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic siqnaling: role of P13-K and Akt kinase upon rac1. Cell Death and Differentiation 10: 508-515, 2003. IF: 8.849

2002

      1. Michitaka Ozaki, Seiichi Suzuki, Kaikobad Irani. : Redox factor-1/APE suppresses oxidative stress by inhibiting activity of the rac1 GTPase. Faseb Journal 16: 889-890, 2002. IF: 5.712
      2. P. Angkeow, S. Deshpande, B. Qi Y-X Liu, Y.C. Park, B. Jeon, M. Ozaki, K. Irani. : Redox factor-1: An extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis. Cell Death and Differentiation 9: 717-725, 2002. IF: 8.849
      3. Mitsufumi Endo, Shin Enosawa, Michitaka Ozaki, Shuichi Tsuruoka, Shinya Hiramatsu, Kazumi Kim, Takeshi Omasa, Toshiharu Matsumura, Tatsuya Aoki, Yasuhisa Koyanagi, Seiichi Suzuki. : Artificial Mimicking of physiological active transport by a membrane co-cultured with two different cells: hepatic origin HepG2 and renal origin PCTL-MDR. Artificial Organs 26:806-811, 2002. IF: 2.000
      4. M.Ozaki*: New strategy for preventing ischemia/reperfusion-induced organ injury and promoting regeneration: A novel trial for improving, transplant organ function by targeted regulation of cellular signals. Transplantation Proceedings 34: 2637-2639, 2002. IF: 1.005
      5. T.Kuroda, S.Enosawa, M.Endo, M.Ozaki, N.Morikawa, S.Suzuki, H.Amemiya. : Early infant kidneys as marginal donor sources: Histology and pathophysiology. Transplantation Proceedings 34: 2582-2584, 2002. IF: 1.005
      6. M.Ozaki*, S.Haga, K. Irani, H.Amemiya, S.Suzuki: Overexpression of redox factor-1 protects against postischemic liver injury by reducing oxidative stress and NF-kappa B activity . Transplantation Proceedings 34: 2640-2642, 2002. IF: 1.005

2001

      1. Ozaki M*, Deshpande S, Angkeow P, Bellan J, Lowenstein CJ, Dinauer MC, Goldschmidt-Clermont P, Suzuki S and Irani K. : Targeted inhibition of the small GTPase protects against ischemia/reperfusion liver injury in mice. Transplantation Proceedings 33, 863-864. 2001. IF: 1.005

2000

      1. Michitaka Ozaki, Shailesh S. Deshpande, Piamsook Angkeow, John Bellan, Charles J. Lowenstein, Mary C. Dinauer, Pascal J. Goldschmidt-Clermont and Kaikobad Irani: Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo. Faseb Journal 14: 418-429, 2000. IF: 5.712
      2. Shailesh S. Deshpande, Piamsook Angkeow, Jianping Huang, Michitaka Ozaki, and Kaikobad Irani: Rac1 Inhibits TNF- -Induced Endothelial Cell Apoptosis: Dual Regulation by Reactive Oxygen Species. Faseb Journal 14, 1705-1714, 2000. IF: 5.712
      3. N. Paolocci, U. E. G. Ekelund, T. Isoda, M. Ozaki, K. Vandegaer, D. Georgakopoulos, R. W. Harrison, D. A. Kass, and J. M. Hare. : cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation. American Journal of Physiology-Heart and Circulatory Physiology 279: H1982-H1988, 2000. IF: 3.708
      4. Michitaka Ozaki, Piamsook Angkeow, Shailesh S. Deshpande, Seiichi Suzuki and Kaikobad Irani: Rac1 regulates stress-induced, redox-dependent heat shock factor activation. Journal of Biological Chemistry 275: 35377-35383, 2000. IF: 4.773

1998

      1. Koichi Tanaka, John D.Pracyk, Kazuyo Takeda, Zu-Xi Yu, Victor J.Ferrans, Shailesh S.Deshpande, Michitaka Ozaki, Paul M.Hwang, Charles J.Lowenstein, Kaikobad Irani, Toren Finkel: Expression of Id1 results in apoptosis of cardiac myocytes through a redox-dependent mechanism. Journal of Biological Chemistry 273: 25922-25928, 1998. IF: 4.773

1997

      1. Michitaka Ozaki*, Michio Nakamura, Satoshi Teraoka, Kazuo Ota: Ebselen, a novel anti-oxidant compound, protects the rat liver from ischemia-reperfusion injury. Transplant International 10:96-102, 1997. IF: 2.921
      2. Michio Nakamura, Michitaka Ozaki, Shohei Fuchinoue, Satoshi Teraoka, Kazuo Ota: Ascorbic acid prevents ischemia-reperfusion injury in the rat small intestine. Transplant International 10: 89-95, 1997. IF: 2.921

1996

      1. Michio Nakamura, Michitaka Ozaki, Shohei Fuchinoue, Satoshi Teraoka, Kazuo Ota. Preventive effects of ascorbic acid on the ischemia/reoxygenation injury in the rat small intestine. Journal of Tokyo Women’s Medical College, 66(11):898-907, 1996. IF: –

1995

      1. S. Teraoka, T. Babazono, O.Tomonaga, S.Sato, M.Nakamura, H.Ishida, T.Hoshino, T.Koike, M.Abe, M.Shinkai, H.Haruguchi, S.Hirotani, K.Kitajima, M.Akamatsu, M.Ozaki, S.Fujita, I.Nakagawa, T.Kawai, S.Fuchinoue, H.Ohgawara, Y.Omori, and K.Ota: Donor criteria and technical aspects of procurement in combined pancreas and kidney transplantation from non-heart-beating cadavers. Transplantation Proceedings 27: 3097-3100, 1995. IF: 1.005
      2. S. Teraoka, T. Babazono, T.Koike, M.Abe, M.Kimikawa, M.Shinkai, H.Haruguchi, S.Hirotani, K.Kitajima, M.Akamatsu, M.Ozaki, S.Fujita, I.Nakagawa, T.Kawai, S.Fuchinoue, K.Ota, O.Tomonaga, K.Yano, Y.Tasaka and Y.Omori: Effect of rescue therapy using FK506 on relapsing rejection after combined pancreas and kidney transplantation. Transplantation Proceedings 27: 1335-1339, 1995. IF: 1.005
      3. Ozaki M*, Fuchinoue S, Teraoka S, Ota K: The in vivo cytoprotection of ascorbic-acid against ischemia reoxygenation injury of rat liver. Archives of Biochemistry and Biophysics 318: 439-445, 1995. IF: 2.935

1994

      1. Michitaka Ozaki*, Shohei Fuchinoue, Satoshi Teraoka, Kazuo Ota: Mobilization ｏｆ low‐molecular‐weight iron and peroxidative damage during Ischemia and reoxygenation of the rat-liver. Transplantation Proceedings 26: 918-921, 1994. IF: 1.005
      2. Michitaka Ozaki*, Hisashi Ozasa, Shouhei Fuchinoue, Satoshi Teraoka, Kazuo Ota: Protective effects of glycine and esterified gamma-glutamylcysteine on ischemia/reoxygenation injury of rat liver. Transplantation 58: 753-755, 1994. IF: 4.003

1988

      1. Michitaka Ozaki*, Teruyuki Kawabata, Michiyasu Awai: Iron release from haemosiderin and production of iron catalysed hydroxyl radical in vitro. Biochemical Journal 250: 589-595, 1988. IF: 4.897

1987

      1. Yoshito Sadahira, Masayasu Mori, Michitaka Ozaki, Michiyasu Awai: Characteristics of histiocytic lesions in the reticuloendothelial system of NZB mice. Acta Pathologica Japonica 37: 1719-1729, 1987. IF: –